506169

InhibitorSelect p53 Pathway Regulators Panel

The InhibitorSelect p53 Pathway Regulators Panel controls the biological activity of InhibitorSelect. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• solubility: DMSO: soluble (supplied)
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

A panel containing 18 potent, selective and cell-permeable inhibitors and 1 activator that is useful for the study of p53 pathway:2 mg of ATM Kinase Inhibitor (Cat. No. 118500),5 mg ATM/ATR Kinase Inhibitor (Cat. No. 118501),10 mg of Anacardic Acid (Cat. No. 172050),5 mg of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699),5 mg of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710),1 mg of Chk2 Inhibitor II (Cat. No. 220486),5 mg of Hdm2 E3 Ligase Inhibitor (Cat. No. 373225),5 mg of JNK Inhibitor II (Cat. No. 420119),1 mg of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143),10 mg of MDMX Inhibitor, SJ-172550 (Cat. No. 444155),5 mg of MG-132 (Cat. No. 474790),5 mg of p21-Activated Kinase Inhibitor III, IPA-3 (Cat. No. 506106),5 mg of Pifithrin-α (Cat. No. 506132),1 mg of PI-103 (Cat. No. 528100),1 mg of PARP Inhibitor VIII, PJ34 (Cat. No. 528150),10 mg of PPM1D Phosphatase Inhibitor (Cat. No. 529578),10 mg of PRIMA-1 (Cat. No. 530050),1 mg of Caspase Inhibitor I (Cat. No. 627610),and 1 mg Trichostatin A, Streptomyces sp. (Cat. No. 647925).Also provided with 15 ml of anhydrous DMSO (Cat. No. KP31817). Supplied with a data sheet.

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Each solutions is stable for up to 3 months at -20°C.

Please refer to information provided on the CD for reconstitution of individual inhibitors.

Other Notes

Feng, Z. and Levine, A.J., 2010. Trends Cell Biol.20, 427.
Wiman, K.G., 2010. Oncogene29, 4245.
Brown, C.J., et al. 2009. Nat. Rev. Cancer9, 862.
Dey, A., et al. 2008. Br. J. Cancer98, 4.
Levine, A.J., et al. 2006. Cell Death Differ.13, 1027.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• hcodes: H412
• pcodes: P273 - P501
• Hazard Classifications: Aquatic Chronic 3
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 188.6 °F - closed cup - (Dimethylsulfoxide)
• flash_point_c: 87 °C - closed cup - (Dimethylsulfoxide)