506163

p38 MAP Kinase Inhibitor VIII

The p38 MAP Kinase Inhibitor VIII, also referenced under CAS 321351-00-2, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): p38 MAP Kinase Inhibitor VIII, (4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
• Empirical Formula (Hill Notation): C₂₀H₁₆BrClN₂O
• CAS Number: 321351-00-2
• Molecular Weight: 415.71
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: ethanol: 15 mg/mL; DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C20H16BrClN2O/c1-12-4-2-3-5-15(12)20(25)16-8-7-14(11-17(16)22)24-19-9-6-13(21)10-18(19)23/h2-11,24H,23H2,1H3
• InChI key: HDCLCHNAEZNGNV-UHFFFAOYSA-N

Description

General description

A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β₂ (82% and 93% inhibition with 1 µM inhibitor, respectively; IC₅₀ of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC′s in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ottosen, E.R., et al. 2003. J. Med. Chem.46, 5651.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable