A biarylurea derivative that acts as a selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR) without substantial activity for α4β2, α3β3 and α1-containing receptors. Exhibits cognitive enhancing effects in vivo.
Biochem/physiol Actions
Primary Target α7 AChR
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Freitas, K., et al., 2013. J. Pharmacol. Exp. Ther.344, 264. Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther.323, 294. Faghih, R., 2007. Recent Pat CNS Drug Discov.2, 99.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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