Selective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
Biochem/physiol Actions
Primary Target D₂
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Grundt, P. et al. 2007. Bioorg. Med. Chem. Lett.17, 745.
Caine, S. B. et al. 2002. J. Neurosci.22, 2977. Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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