5.05736

5-BDBD

• Synonym(s): 5-BDBD, 5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD
• Empirical Formula (Hill Notation): C₁₇H₁₁BrN₂O₂
• CAS Number: 768404-03-1
• Molecular Weight: 355.19
• MDL number: MFCD18086878
• UNSPSC Code: 12352200

Properties

• assay: ≥99% (HPLC)
• Quality Level: 100
• form: powder
• potency: 500 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 15 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)
• InChI key: NKYMVQPXXTZHSF-UHFFFAOYSA-N

Description

General description

A highly potent antagonist of purinergic P2X₄ receptor. Shown to block P2X₄-mediated currents in Chinese hamster ovary cells (IC₅₀ = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.

Biochem/physiol Actions

Primary Target
P2X₄

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Trabanelli, S., et al. 2012. J. Immunol.189, 1303.
Wu, T., et al. 2011. Am. J. Physiol.301, H69.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable