5.05316

PHA-543,613

• Synonym(s): PHA-543,613, N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, Alpha 7 Nicotinic Acetylcholine Receptor (α7 nAChR) Agonist, PHA-543613
• Empirical Formula (Hill Notation): C₁₅H₁₇N₃O₂
• CAS Number: 478149-53-0
• Molecular Weight: 271.31
• UNSPSC Code: 12352200

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 20 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1
• InChI key: IPKZCLGGYKRDES-ZDUSSCGKSA-N

Description

General description

A potent agonist highly selective for α7 nicotinic acetylcholine receptor (α7 nAChR). Bioavaible admitted orally. Widely used in studies of the functional roles of α7 nAChR in learning and memory, sensory gating, and cognitive functions as well as Schizophrenia and Alzheimer′s disease.

Biochem/physiol Actions

Primary Target
α7 nAChR

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Mazurov, A., et al., 2011. J. Med. Chem.54, 7943.
Wishka, G., et al., 2006. J. Med. Chem.49, 4425.
Faghih, R., et al., 2008. J. Med. Chem.51, 701.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable