5.04345

BX471

• Synonym(s): BX471, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
• Empirical Formula (Hill Notation): C₂₁H₂₄ClFN₄O₃
• CAS Number: 217645-70-0
• Molecular Weight: 434.89
• UNSPSC Code: 12352200

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• potency: 1-5 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white to beige
• solubility: DMSO: ≥25 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
• InChI key: XQYASZNUFDVMFH-CQSZACIVSA-N

Description

General description

An orally active, selective antagonist for chemokine receptor 1 (CCR-1) (K_i = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.

Biochem/physiol Actions

Primary Target
CCR1

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shahlaei, M., et al. 2011. J. Chemical Information and Modeling.51, 2717.

Reuss, R., et al. 2010. Mult Scler.16, 366.

Gladue, R., et al. 2010. Curr Top Med Chem10, 1268.

Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol.68, 435.

Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry.5, 791.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_c: Not applicable