5.00486

CXCR3 Antagonist

• Synonym(s): CXCR3 Antagonist, GPR9 Antagonist, 4-cyano-N-(3-fluoro-4-(1H-tetrazol-5-yl)benzyl)-N-(2-fluorobenzyl)benzenesulfonamide, AS612568, EMD1205395, CD183 Antagonist
• Empirical Formula (Hill Notation): C₂₂H₁₆F₂N₆O₂S
• CAS Number: 1191066-94-0
• Molecular Weight: 466.46
• UNSPSC Code: 12352200

Properties

• assay: ≥95% (HPLC)
• Quality Level: 100
• form: solid
• potency: 192 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 50 mg/mL
• storage temp.: 2-8°C

Description

General description

An arylsulfonamide derivative that acts as a CXCR3 antagonist (IC₅₀ = 192 nM against CXCL10-induced chemotaxis of hCXCR3-overexpressing L1.2 cells) with good aqueous solubility (>100 µM at pH 7.4). Shown to be orally available in mice (83% bioavailability; t_1/2 = 1 h; 10 mg/kg p.o.) in vivo and display a medium intrinsic clearance (CI_int = 17 µL/min/mg) in in vitro mouse liver microsome stability test.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
CXCR3

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C).

Other Notes

Crosignani, S., et al. 2010. Bioorg. Med. Chem. Lett.20, 3614.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany