496150

Omi/HtrA2 Protease Inhibitor, Ucf-101

The Omi/HtrA2 Protease Inhibitor, Ucf-101, also referenced under CAS 313649-08-0, controls the biological activity of Omi/HtrA2 Protease. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(s): Omi/HtrA2 Protease Inhibitor, Ucf-101, High Temperature Requirement A2 Inhibitor I, 5-[5-(2-Nitrophenyl)furfurylidine]-1,3-diphenyl-2-thiobarbituric Acid
• Empirical Formula (Hill Notation): C₂₇H₁₇N₃O₅S
• CAS Number: 313649-08-0
• Molecular Weight: 495.51
• MDL number: MFCD01000361
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: orange
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C27H19N3O5S/c31-25-22(17-20-15-16-24(35-20)21-13-7-8-14-23(21)30(33)34)26(32)29(19-11-5-2-6-12-19)27(36)28(25)18-9-3-1-4-10-18/h1-17,33-34H
• Inchi Key: QMGXAGWZCHDZRG-UHFFFAOYSA-N

Description

General description

A cell-permeable furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2 (IC₅₀ = 9.5 µM for His-Omi_134-458). Shows very little activity against various other serine proteases tested (IC₅₀ ≥ 200 µM). Reported to block Omi/HtrA2 induced cell death in caspase-9 (-/-) null fibroblasts.

A cell-permeable, furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease, Omi/HtrA2 (IC₅₀ = 9.5 µM for His-Omi_134-458). Reported to inhibit Omi/HtrA2-induced cell death in caspase-9 (-/-) null fibroblasts. Does not significantly inhibit other serine proteases, including kallikrein, trypsin, plasmin, thrombin, and tissue plasminogen activator (t-PA) (IC₅₀ ≥200 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2

Product does not compete with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Cilenti, L., et al. 2003. J. Biol. Chem.278, 11489.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable