481414

NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem

The NF-κB Activation Inhibitor VI, BOT-64, also referenced under CAS 113760-29-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Synonym(s): NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem, 6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one
• Empirical Formula (Hill Notation): C₁₅H₁₅NO₂S
• CAS Number: 113760-29-5
• Molecular Weight: 273.35
• UNSPSC Code: 12352200

Properties

• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: ethanol: 10 mg/mL; DMSO: 50 mg/mL
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

A cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser¹⁷⁷ and/or Ser¹⁸¹ residues in the kinase′s activation loop domain. Shown to inhibit LPS-induced NF-κB activation and nitrite production (IC₅₀ = 1.0 & 0.7 µM, respectively) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice (70% survival rate with 30 mg/kg BOT-64, i.p.) in vivo.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Kim, B.H., et al. 2008. Mol. Pharmacol.73, 1309.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable