480703-M

Neurodazine

A cell-permeable trisubstituted imidazole compound that induces neurogenesis of non-pluripotent C2C12 myoblasts as well as cells derived from mature human skeletal muscle cultures (2 µM for 7-10 days).

• Synonym(s): Neurodazine, 2-(2-(5-(3-Chlorophenyl))furanyl)-4,5-bis-(4-methoxyphenyl)-imidazole, Nz
• Empirical Formula (Hill Notation): C₂₇H₂₁ClN₂O₃
• CAS Number: 937807-66-4
• Molecular Weight: 456.92
• MDL number: MFCD08906055
• UNSPSC Code: 12352200

Properties

• assay: ≥98% (HPLC)
• form: film
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30)
• InChI key: FEEOFPAEDSMOTO-UHFFFAOYSA-N

Description

General description

A cell-permeable trisubstituted imidazole compound that induces neurogenesis of non-pluripotent C2C12 myoblasts as well as cells derived from mature human skeletal muscle cultures (2 µM for 7-10 days). Shown to preferentially upregulate genes involved in neurogenesis, but not those pertaining to myogenesis, in C2C12 myoblasts.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Williams, D.R., et al. 2007. J. Am. Chem. Soc.129, 9258.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: 668.8 °F
• flash_point_c: 353.8 °C