47589-M

Mitomycin C, Streptomyces caespitosus

• Synonym(s): Mitomycin C, Streptomyces caespitosus, Mitocin C, MMC
• Empirical Formula (Hill Notation): C₁₅H₁₈N₄O₅
• CAS Number: 50-07-7
• Molecular Weight: 334.33
• MDL number: MFCD00078109
• UNSPSC Code: 12352200

Properties

• assay: ≥95% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: blue-violet
• solubility: water: 1 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
• InChI key: NWIBSHFKIJFRCO-WUDYKRTCSA-N

Description

General description

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues, disrupting base pairing. Induces apoptosis in gastic cancer cells. Blocks the cell cycle at the G2 phase.

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Forms covalent adducts into deoxyguanine and guanine under acidic conditions. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G₂ phase.

Warning

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Physical form

Provided as 2 mg antibiotic and 48 mg NaCl.

Reconstitution

Following reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.

Other Notes

Kruyt, F.A., et al. 1996. Blood 89, 938.
Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst.87, 1394.
Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
Kawasaki, S., et al. 1992. Jpn. J. Cancer Res.83, 899.
Malkinson, A.M., et al. 1992. Cancer Res.52, 4752.
McEvoy, J.L., et al. 1992. J. Bacteriol.174, 5471.
Tomasz, M., et al. 1987. Science235, 1204.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H351
• pcodes: P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable