475816
Microcystin-RR, Microcystis aeruginosa - CAS 111755-37-4 - Calbiochem
Synonym(s):
MCYST-RR
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About This Item
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
solid
color
off-white
solubility
DMSO: 2.5 mg/mL
ethanol: soluble
General description
Arg-Arg analog of Microcystin-LR (Cat. No. 475815) that is less toxic. Inhibitor of protein-phosphatase 2A (IC50 = 3.4 nM). Useful for comparative structure and function studies.
Biochem/physiol Actions
Target IC50:3.4 nM inhibiting protein phosphatase 2A
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Not available for sale outside of the United States.
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Certificates of Analysis (COA)
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M Shirai et al.
Applied and environmental microbiology, 57(4), 1241-1245 (1991-04-01)
All samples of cyanobacterial blooms collected from 1986 to 1989 from Lake Kasumigaura, Ibaraki Prefecture, Japan, were hepatotoxic. The 50% lethal doses (LD50s) of the blooms to mice ranged from 76 to 556 mg/kg of body weight. Sixty-eight Microcystis cell
R Matsushima et al.
Biochemical and biophysical research communications, 171(2), 867-874 (1990-09-14)
Three microcystins, YR, LR and RR and nodularin, all of which are hepatotoxic compounds, inhibited dose-dependently the activity of protein phosphatase 2A in and the specific [3H]okadaic acid binding to a cytosolic fraction of mouse skin, as strongly as okadaic
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