370674

Guanosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt

• Synonym(s): Guanosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt, Rp-8-Br-cGMPS, Na, PKG Inhibitor II
• Empirical Formula (Hill Notation): C₁₀H₁₀BrN₅O₆PS · Na
• Molecular Weight: 462.15
• UNSPSC Code: 12352200

Properties

• assay: ≥99% (HPLC)
• Quality Level: 100
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A potent cell-permeable, metabolically stable inhibitor of cGMP-dependent protein kinase (PKG). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases.

A potent, cell-permeable, and metabolically stable inhibitor of protein kinase G (PKG; K_i = 4 µM). Acts as a cyclic nucleotide-gated channel agonist (EC₅₀ = 173.5 µM). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Note: 5 µmol = 2.31 mg.

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Target K_i: 4 µM against protein kinase G (PKG)

Warning

Toxicity: Standard Handling (A)

Other Notes

Wei, J.Y., et al. 1998. J. Mol. Neurosci. 10, 53.
Nakamura, A., et al. 1996. Br. J. Pharmacol.117, 407.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94.
Nakazawa, M., et al. 1994. Eur. J. Pharmacol.253, 179.
Zhuo, M., et al. 1994. Nature368, 635.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable