361568

GSK-3β Inhibitor XXV

The GSK-3β Inhibitor XXV controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): GSK-3β Inhibitor XXV, 5-(4-Nitrophenyl)-N-(3-chloro-4-methyl)phenyl-1,3,4-oxadiazol-2-amine, N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine, M SEW00923SC
• Empirical Formula (Hill Notation): C₁₅H₁₁ClN₄O₃
• CAS Number: 1257256-44-2
• Molecular Weight: 330.73
• MDL number: MFCD22683811
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥99% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: CC(C=C1)=C(Cl)C=C1NC2=NN=C(C3=CC=C(C=C3)[N+]([O-])=O)O2

Description

General description

A blood brain barrier permeable oxadiazole compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3β activity (IC₅₀ = 17.1 nM) with excellent selectivity over Cdk2 (22% inhibition at 10 µM). Shown to elevate liver glycogen levels by ~3.5- and ~4.3-fold in C57BL/6N mice when dosed at 5 and 15 mg/kg (i.p.) amounts.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Khanfar, M.A., et al. 2010. J. Med. Chem.53, 8534.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable