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345744

Sigma-Aldrich

Ganglioside GT1b, Trisialo, Triammonium Salt, Bovine Brain

Inhibits Con A-stimulated mitogenesis in murine T cells.

Synonym(s):

Ganglioside GT1b, Trisialo, Triammonium Salt, Bovine Brain, Neu5Acα2,3Galβ1,3GalNAcβ1,4(Neu5Acα2,8Neu5Acα2,3)Galβ1,4Glcβ1,1 Ceramide, 3NH₄

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About This Item

Empirical Formula (Hill Notation):
C95H162N5O47 · 3NH4
Molecular Weight:
2180.42
UNSPSC Code:
12352211
NACRES:
NA.77

Quality Level

100

assay

≥98% (TLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

ethanol: soluble
methanol: soluble

shipped in

ambient

storage temp.

−20°C

General description

Inhibits Con A-stimulated mitogenesis in murine T cells. Lymphocyte marker in cancer patients. Readily converted to GD1b-disialoganglioside by bacterial and other mammalian neuraminidases without detergent or bile salts.
M.W. 2180.5 (based on stearoyl - 18:0).
Trisialoganglioside prepared from bovine gray matter. Readily converted to GD1b-disialoganglioside by bacterial and mammalian sialidases without detergent or bile salts. Inhibits mitogenesis in concanavalin A-stimulated murine T-cells. Lymphocyte marker in cancer patients.



Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Inhibits Con A-stimulated mitogenesis in murine T cells
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Irritant (B)

Preparation Note

For use in aqueous systems, dissolve in a small amount of ethanol and then sonicate in buffer or medium, or dissolve the dried sample directly in aqueous buffers by sonication. Solutions can be filter sterilized.

Reconstitution

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Hakomori, S. 1985. Cancer Res.45, 2405.
Momoi, T., et al. 1976. Biochim. Biophys. Acta441, 488.
Warren, L. 1959. J. Biol. Chem.234, 1971.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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