344039

cFMS Receptor Inhibitor IV

The cFMS Receptor Inhibitor IV, also referenced under CAS 959626-45-0, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): cFMS Receptor Inhibitor IV, 5-Cyano-N-(2,5-di(piperidin-1-yl)phenyl)furan-2-carboxamide, CSF-1 Receptor Inhibitor IV
• Empirical Formula (Hill Notation): C₂₂H₂₆N₄O₂
• CAS Number: 959626-45-0
• Molecular Weight: 378.47
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 5 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C22H26N4O2/c23-16-18-8-10-21(28-18)22(27)24-19-15-17(25-11-3-1-4-12-25)7-9-20(19)26-13-5-2-6-14-26/h7-10,15H,1-6,11-14H2,(H,24,27)
• InChI key: FQGXFVDABCBEFW-UHFFFAOYSA-N

Description

General description

A cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive cFMS/CSF-1R inhibitor that blocks cFMS autophosphorylation both in CSF-1/M-CSF-stimulated HEK-293 cells (IC₅₀ = 76 nM) and in cell-free in vitro kinase assays (IC₅₀ = 17 nM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Patch, R.J., et al. 2007. Bioorg. Med. Chem. Lett.17, 6070.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2