343020

Flt-3 Inhibitor

The Flt-3 Inhibitor, also referenced under CAS 301305-73-7, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): Flt-3 Inhibitor
• Empirical Formula (Hill Notation): C₁₈H₂₀N₂O₄S
• CAS Number: 301305-73-7
• Molecular Weight: 360.43
• MDL number: MFCD00617269
• UNSPSC Code: 12352106
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: <4 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
• InChI key: FSPQCTGGIANIJZ-UHFFFAOYSA-N

Description

General description

A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC₅₀ = 42 nM) with little effect against a panel of 22 other kinases (IC₅₀ ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC₅₀ = 340 nM) expressing constitutively active Flt-3.

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target IC₅₀: 42 nM against Flt-3

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Other Notes

Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett.16, 3282.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3