324378
Domoic Acid, Mytilus edulis - CAS 14277-97-5 - Calbiochem
Synonym(s):
25-[2α, 3β, 4β (1Z, 3E, 5R)]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic Acid
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About This Item
Recommended Products
assay
≥95% (HPLC)
Quality Level
form
crystalline solid
color
white to off-white
solubility
methanol: 0.6 mg/mL
H2O: 8 mg/mL
General description
A heat-stable neurotoxin. Glutamate kainate receptor agonist that shows higher affinity for the kainate receptor than any other known kainic acid analog. Causes excessive excitation of neurons resulting in the depletion of energy stores, cellular edema, and death. Inhibits adenylate cyclase activity in neuronal membranes. Evokes Ca2+-dependent and Ca2+-independent release of GABA.
Glutamate kainate excitatory amino acid agonist with the highest affinity for the kainate receptor of all known kainic acid analogs. It has been used to purify the kainate receptor by affinity chromatography. Its binding to the receptor causes continuous stimulation of nerve cells leading to depletion of energy, cellular edema, and death. Its neurological effect resembles anterograde memory loss associated with Alzheimer′s disease. Inhibits adenylate cyclase activity in brain membranes. Evokes Ca2+-dependent and Ca2+-independent release of GABA.
Biochem/physiol Actions
Glutamate kainate receptor
Reconstitution
Following reconstitution, store in the refrigerator (4°C). Do not freeze solutions. Stock solutions are stable for up to 24 h at 4°C.
Storage Class
10-13 - German Storage Class 10 to 13
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M Alfonso et al.
Neurochemistry international, 24(3), 267-274 (1994-03-01)
The effect of the neurotoxin domoic acid (DOM), a structural analogue of kainic acid, on the release of [3H]gamma-aminobutyric acid (GABA) and on the [Ca2+]i was studied in cultured chick retina cells. DOM stimulated dose-dependently the release of [3H]GABA with
G R Stewart et al.
Experimental neurology, 110(1), 127-138 (1990-10-01)
Domoic acid (Dom), a rigid analog of the excitotoxic amino acids, glutamate and kainic acid, is believed to be the mussel neurotoxin responsible for a recent food poisoning incident in Canada that killed some people and left others with memory
M S Nijjar et al.
Molecular and cellular biochemistry, 136(2), 105-111 (1994-07-27)
Adenylate cyclase activity measured by the formation of cyclic AMP in rat brain membranes was inhibited by a shellfish toxin, domoic acid (DOM). The inhibition of enzyme was dependent on DOM concentration, but about 50% of enzyme activity was resistant
P N Usherwood et al.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 103(1), 19-22 (1992-09-01)
1. A review is presented of recent advances in glutamate receptor research with particular emphasis on studies which show that some glutamate receptors in the central nervous systems (CNS) of Xenopus and rat contain a mixture of N-methyl-D-aspartate-sensitive and kainate-sensitive
R A Tasker et al.
Canadian journal of physiology and pharmacology, 69(3), 378-382 (1991-03-01)
Domoic acid, a structural analogue of kainic acid, has been identified as the toxin that poisoned people who consumed contaminated blue mussels harvested from eastern Prince Edward Island in December of 1987. To investigate the pharmacology of domoic acid in
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