218841

InSolution Caspase-9 Inhibitor I - Calbiochem

The InSolution Caspase-9 Inhibitor I controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(s): InSolution Caspase-9 Inhibitor I - Calbiochem, Z-LE(OMe)HD(OMe)-FMK
• Empirical Formula (Hill Notation): C₃₂H₄₃FN₆O₁₀
• Molecular Weight: 690.72
• UNSPSC Code: 12352200

Properties

• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

A 5 mM (250 µg/72 µl) solution of Z-LEHD-FMK (Cat. No. 218761) in DMSO. A potent, cell-permeable, and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-4, caspase-5, caspase-9

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Sequence

Z-Leu-Glu(OMe)-His-Asp(OMe)-CH₂F*

Physical form

A 5 mM solution of Z-LEHD-FMK (Cat. No. 218761) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Analysis Note

single spot by TLC

Other Notes

Fadeel, B., et al. 1999. Leukemia13, 719.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 188.6 °F - (refers to pure substance)
• flash_point_c: 87 °C - (refers to pure substance)