218840

Caspase-8 Inhibitor II

InSolution

• Synonym(s): InSolution Caspase-8 Inhibitor II, Granzyme B Inhibitor III; Z-IE(OMe)TD(OMe)-FMK
• Empirical Formula (Hill Notation): C₃₀H₄₃FN₄O₁₁
• Molecular Weight: 654.68
• UNSPSC Code: 12352200
• NACRES: NA.54

Properties

• Quality Level: 100
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO. Z-IETD-FMK is a potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-8

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Sequence

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Physical form

A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Analysis Note

≥98% (HPLC)

Other Notes

Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 188.6 °F - (refers to pure substance)
• flash_point_c: 87 °C - (refers to pure substance)