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Key Documents

COA/COQ

218712

Anti-Casein Kinase II, β-Subunit Mouse mAb (6D5)

Name: Anti-Casein Kinase II, β-Subunit Mouse mAb (6D5)
Brand: MM

lyophilized, clone 6D5, Calbiochem^®

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About This Item

UNSPSC Code:

12352203

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

6D5, monoclonal

form

lyophilized

does not contain

preservative

species reactivity

human, mouse, hamster, bovine

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

isotype

IgG

shipped in

wet ice

storage temp.

−20°C

General description

Anti-Casein Kinase II, β-Subunit, mouse monoclonal, clone 6D5, recognizes recombinant CKII β-subunit and native holoenzyme. It is validated for Western blotting and immunocytochemistry.

Protein A purified mouse monoclonal antibody. Recognizes the ~25 kDa CKII β-subunit.

Recognizes recombinant CKII β-subunit and native holoenzyme.

Immunogen

Human

purified, recombinant, human CKII β-subunit

Application

Immunoblotting (5 µg/ml)

Immunocytochemistry (5 µg/ml)

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from PBS.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.

Other Notes

Nastainczyk, W., et al. 1995. Hybridoma 14, 335.

Variables associated with assay conditions will dictate the proper working dilution.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS07,GHS08

signalword

Danger

hcodes

H319 - H360FD

pcodes

P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Repr. 1B

Storage Class

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator.

Aron Szabó et al.

PLoS biology, 11(8), e1001645-e1001645 (2013-09-10)

Phosphorylation is a pivotal regulatory mechanism for protein stability and activity in circadian clocks regardless of their evolutionary origin. It determines the speed and strength of molecular oscillations by acting on transcriptional activators and their repressors, which form negative feedback

Casein kinase activity in etiolated Cucumis sativus cotyledons.

D Vidal et al.

Plant biology (Stuttgart, Germany), 12(1), 134-144 (2010-07-27)

Two calcium- and light-dependent protein kinases have been reported in etiolated Cucumis sativus cotyledons (Vidal et al. 2007). In the present work, we studied casein kinase (CK) activity in etiolated cucumber cotyledons of in-gel and in vitro kinase assays, using

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.

Tsuyoshi Oshima et al.

Science advances, 5(1), eaau9060-eaau9060 (2019-02-13)

Compounds targeting the circadian clock have been identified as potential treatments for clock-related diseases, including cancer. Our cell-based phenotypic screen revealed uncharacterized clock-modulating compounds. Through affinity-based target deconvolution, we identified GO289, which strongly lengthened circadian period, as a potent and

Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α' subunits reduces orthotopic xenograft prostate tumors in mice.

Janeen H Trembley et al.

Molecular and cellular biochemistry, 356(1-2), 21-35 (2011-07-16)

CK2 is a highly conserved, ubiquitous, signal responsive protein serine/threonine kinase. CK2 promotes cell proliferation and suppresses apoptosis, and increased CK2 expression is observed in all cancers examined. We previously reported that direct injection of antisense (AS) CK2α phosphorothioate oligonucleotides

CK2 inhibitor CX-4945 blocks TGF-β1-induced epithelial-to-mesenchymal transition in A549 human lung adenocarcinoma cells.

Jiyeon Kim et al.

PloS one, 8(9), e74342-e74342 (2013-09-12)

The epithelial-to-mesenchymal transition (EMT) is a major phenotype of cancer metastasis and invasion. As a druggable cancer target, the inhibition of protein kinase CK2 (formally named to casein kinase 2) has been suggested as a promising therapeutic strategy to treat

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