203697
BPDQ
A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 120 pM).
Synonym(s):
BPDQ, 4-[(3-Bromophenyl)amino]-6,7-diaminoquinazoline
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About This Item
Empirical Formula (Hill Notation):
C14H12BrN5
CAS Number:
Molecular Weight:
330.18
UNSPSC Code:
12352200
Recommended Products
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 0.12 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
EGFR
EGFR
Product competes with ATP.
Reversible: yes
Target IC50: 120 pM against EGFR
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). This product is stable for up to 3 months at -20°C.
Other Notes
Rewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.
Rewcastle, G.W., et al. 1995. J. Med. Chem. 38, 3482.
Rewcastle, G.W., et al. 1995. J. Med. Chem. 38, 3482.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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