19-137
Sodium Butyrate
For use as a histone deacetylase inhibitor.
Synonym(s):
Butyric acid sodium salt
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About This Item
UNSPSC Code:
41116012
eCl@ss:
32160405
NACRES:
NA.41
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Quality Level
form
liquid
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (histone deacetylase (HDAC))
shipped in
wet ice
Application
Sodium Butyrate has been used:
- to inhibit histone deacetylase (HDAC) and study its effect on fibroblast growth factor 21 (FGF21) expression in liver
- to inhibit deacetylase activity in embryonic stem (ES) cells to determine if the enzymatic activity of the mSin3A-HDAC complex is essential for Nanog expression
- as a reagent during tissue homogenization
- as a supplement in chromatin immunoprecipitation (ChIP) dilution buffer
Biochem/physiol Actions
Sodium Butyrate is a short-chain fatty acid and a histone deacetylase inhibitor. It protects dopaminergic neuronal cells from α-synuclein mediated transcriptional deregulation and DNA damage, maybe by enhancing the expression of DNA-repair genes. Sodium butyrate may promote the production of foreign proteins such as erythropoietin, tissue plasminogen activator, antibody, and nitric oxide synthase in recombinant Chinese hamster ovary (rCHO) cell cultures. But, the higher concentration of sodium butyrate in rCHO cell cultures may also exhibit a cytotoxic effect on cell growth by inducing apoptosis. Sodium Butyrate prevents the growth of cancer cells by downregulating the thioredoxin 1 (Trx1) expression, stimulating reactive oxygen species (ROS) production, and inhibiting cell proliferation and migration of various carcinoma cells including colorectal cancer (CRC).
Physical form
CH3CH2CH2COONa
Storage and Stability
1 year at 4°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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No Soo Kim et al.
Biotechnology and bioengineering, 78(2), 217-228 (2002-03-01)
Sodium butyrate (NaBu) can enhance the expression of genes controlled by some of the mammalian promoters, but it can also inhibit cell growth and induce cellular apoptosis. Thus, the beneficial effect of using a higher concentration of NaBu on a
Isabel Paiva et al.
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Alpha-synuclein (aSyn) is considered a major culprit in Parkinson's disease (PD) pathophysiology. However, the precise molecular function of the protein remains elusive. Recent evidence suggests that aSyn may play a role on transcription regulation, possibly by modulating the acetylation status
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Febs Letters, 353, 225-229 (1994)
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Sodium butyrate (NaB) is a short-chain fatty acid which is produced by bacterial fermentation of nondigestible dietary fiber and has been reported to exert anti-tumor effects in many tumors including colorectal cancer (CRC). However, the role of thioredoxin-1 (Trx-1) in
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Proceedings of the National Academy of Sciences of the USA, 94, 10279-10284 (1997)
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