124028-M
Akt Inhibitor XI - Calbiochem
Synonym(s):
3-Formylchromone thiosemicarbazone, Cu(II)Cl₂ Complex, FPA-124
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About This Item
UNSPSC Code:
12352200
Pricing and availability is not currently available.
assay
≥98% (elemental analysis)
form
solid
color
green
solubility
DMSO: 2 mg/mL
H2O: 5 mg/mL
General description
A cell-permeable copper complex (Cu2+/Cu+ redox couple in the range of +0.28 to +0.35 V) that interacts with both the PH and the kinase domains of Akt and potently inhibits its kinase activity (IC50 = 100 nM). Inhibits tumor growth both in cultured cells in vitro (IC50 ranges from 10 to 34 μM) and in mice in vivo (25 mg/kg, iv) without any apparent adverse effect to the animals.
The Akt Inhibitor XI controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Biochem/physiol Actions
Target IC50:100 nM against Akt
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Vivek Barve et al.
Journal of medicinal chemistry, 49(13), 3800-3808 (2006-06-23)
The synthesis and characterization of Schiff base derivatives of 3-formylchromone 3-6 (FPA-120 to FPA-123), the minimal biologically active structural motif of soy isoflavone, genistein, and their copper(II) complexes 7-10 (FPA-124 to FPA-127) are reported here. These copper complexes possess distorted
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