119120

Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

• Synonym(s): Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt, ATP-γ-S, 4Li
• Empirical Formula (Hill Notation): C₁₀H₁₂N₅O₁₂P₃S · 4Li
• CAS Number: 93839-89-5
• Molecular Weight: 546.98
• MDL number: MFCD00077293
• UNSPSC Code: 12352208
• NACRES: NA.51

Properties

• Quality Level: 100
• assay: ≥85% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• impurities: <10% ADP
• color: white
• solubility: water: 10 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
• InChI key: DWQFDOIBOYDYKH-KWIZKVQNSA-J

Description

General description

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases activity of Ca²⁺-activated K⁺ channels. Used as an inhibitor of ATP-dependent enzyme systems.

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases the activity of Ca²⁺-activated K⁺ channels. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

Application

• Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.: This study explores the role of purinergic receptors and the NOD-like receptor-family protein 3 (NLRP3) inflammasome pathway in cytokine release induced by adenosine triphosphate (ATP) in macrophages. The findings suggest potential therapeutic targets for inflammatory diseases (Gicquel et al., 2014).


• Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries.: The study demonstrates that extracellular ATP enhances flow-induced vasodilation in small mesenteric arteries in rats, indicating a significant role of ATP in vascular function and potential implications for cardiovascular therapies (Liu et al., 2004).

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.

Other Notes

Troadec, J.D., et al. 1999. Pflugers Arch. 437, 745.
Chung, S., et al. 1991. Science253, 560.
Litosch, I., and Fain, J.N. 1986. Life Sci. 39, 187.
Chrysogelos, S., et al. 1983. J. Biol. Chem.258, 12624.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable