07-1223

Anti-Protein Phosphatase 2 C α/β Antibody

from rabbit

• Synonym(s): Protein phosphatase 2C, Pyruvate dehydrogenase, Pyruvate dehydrogenase phosphatase, catalytic subunit 1, Lipoamide-phosphatase 1, mitochondrial precursor, Protein phosphatase 2C, magnesium-dependent, catalytic subunit, Pyruvate dehydrogenase (Lipoamide)
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: bovine, human, rat
• species reactivity (predicted by homology): mouse
• technique(s): western blot: suitable
• UniProt accession no.: Q9P0J1
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... PDP1(54704)

Description

General description

PP-2 C α/β is heterodimer located in the mitochondrial matrix. Within the pyruvate dehydrogenase complex, PP-2 C α/β serves to catalyze the dephosphorylation and concomitant reactivation of the E1 component’s alpha subunit. Mutations occurring in the PDP1 gene are the cause of a disease known as pyruvate dehydrogenase deficiency (PDP deficiency), which leads to neurological dysfunction from lactic acidosis.

Specificity

Recognizes the alpha/beta regulatory subunit isotype of protein phosphatase 2C (PP2C). PP 2C alpha/beta polyclonal antibody binds a 44-46 kDa protein.

Immunogen

Purified peptide conjugated to KLH.

Application

Detect Protein Phosphatase 2 C α/β using this Anti-Protein Phosphatase 2 C α/β Antibody validated for use in WB.

Research Category
Signaling

Research Sub Category
Kinases & Phosphatases

Quality

Evaluated by Western Blot in L6 cell lysates.
Western Blot Analysis: 1:500 dilution of this lot detected PP-2 C ALPHA/BETA on 10 ug of L6 lysates.

Target description

Approx. 46 kDa

Linkage

Replaces: AB4090

Physical form

Format: Purified

Protein Purified

Purified immunoglobulin in phosphate buffered saline with 0.08% sodium azide.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.

Analysis Note

Control
L6 Cell Lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable