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03-0127-00

Millipore

SMC® Mouse IL-22 Discovery Immunoassay Kit

Synonym(s):

mouse IL 22 immunoassay kit, mouse IL-22 Single Molecule Counting Kit, mouse IL-22 ultra-sensitive immunoassay, mouse Interleukin 22 immunoassay kit

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000

species reactivity

mouse

manufacturer/tradename

SMC®

assay range

accuracy: 80-120%
(minimum of 10 samples spiked with acceptable recovery)

technique(s)

ELISA: suitable
single molecule counting: suitable

General description

Interleukin-22 (IL-22), also known as IL-10-related T-cell derived inducible factor (IL-TIF), is a member of the IL-10 cytokine family. Mainly produced by activated T-cells and natural killer cells, IL-22 binds to a receptor complex with two components, CRF2-4 and IL-22R. The signaling cascade is said to up-regulate pro-inflammatory cytokines and antimicrobial peptides, and induce production of acutephase reactants in liver and hepatoma cells. The biological function of IL-22 is associated with many inflammatory disorders, including Crohn′s disease, inflammatory bowel disease, psoriasis, rheumatoid arthritis and ulcerative colitis. Thus, IL-22 remains an attractive therapeutic target because of its pro-inflammatory properties.
The SMC® Mouse IL-22 Discovery Immunoassay Kit contains all reagents required to perform the assay. This assay takes advantage of a standard immunoassay workflow configured in a standard plate format. Assay protocols are similar to existing sandwich ELISA methods with two key differences: 1) Elution buffer disrupts the sandwich, separating the labeled detection antibody for quantification. 2) The SMC® immunoassay system detects analytes using Single Molecule Counting (SMC®) technology.

Application

Research Category
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
The sensitivity of Single Molecule Counting (SMC®) technology gives the SMC® Mouse IL-22 Discovery Immunoassay unparalleled performance in the quantification of IL-22 in mouse serum.
Used to detect/quantify:IL-22

Components

Assay Buffer
Mouse IL-22 Coating Antibody
Assay Plate
10X PBS
Blocking Buffer
Standard Diluent
Mouse IL-22 Detection Antibody
Mouse IL-22 Standard
SMC® Mouse IL-22 Immunoassay Kit Instructions
10X Wash Buffer
Buffer C
Elution Buffer B

Legal Information

SMC is a registered trademark of Singulex

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

pictograms

Health hazardExclamation mark
GHS08,GHS07

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Danger

Hazard Classifications

Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Certificates of Analysis (COA)

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