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R-026

Supelco

Remifentanil acid solution

100 μg/mL in acetonitrile, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C19H26N2O5
CAS Number:
132875-68-4
Molecular Weight:
362.42
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

InChI

1S/C19H26N2O5/c1-3-16(22)21(15-7-5-4-6-8-15)19(18(25)26-2)10-13-20(14-11-19)12-9-17(23)24/h4-8H,3,9-14H2,1-2H3,(H,23,24)

InChI key

GFJKFSFFMHOISI-UHFFFAOYSA-N

General description

Remifentanil acid is the major urinary metabolite of remifentanil, a synthetic opioid used to induce or supplement general anesthesia. This new certified reference solution is suitable for a variety of mass spectrometry-based testing applications including clinical toxicology, forensic analysis, workplace drug testing and pharmaceutical research.

Application


  • Glycogen synthase kinase-3 beta inhibition prevents remifentanil-induced postoperative hyperalgesia via regulating the expression and function of AMPA receptors: This study investigates the mechanisms behind remifentanil-induced hyperalgesia, using remifentanil acid as a key component to understand pain modulation post-surgery. The findings are essential for developing targeted pain management therapies in postoperative care, making it a crucial study for researchers in pharmaceutical and analgesic drug development (Li et al., 2014).

  • Quantitative measurement of blood remifentanil concentration: development of a new method and clinical application: This research develops a new methodology for quantifying blood levels of remifentanil, providing insights into its pharmacokinetics and pharmacodynamics. This method is significant for clinical settings where precise dosing and monitoring are crucial, offering valuable data for pharmacological research and safe anesthetic practices (Kudo et al., 2013).

  • Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration: This groundbreaking study explores the potential for high-dose opioids like remifentanil to erase painful memories at the spinal level, potentially revolutionizing approaches to chronic pain management. This research is of paramount importance to neuroscientists and clinical researchers focusing on new therapeutic strategies for pain relief (Drdla-Schutting et al., 2012).

  • Distinct mechanisms underlying pronociceptive effects of opioids: This study further elucidates the complex mechanisms by which opioids like remifentanil may exacerbate pain under certain conditions. By exploring the molecular interactions involved, this research contributes to a deeper understanding of opioid pharmacology and aids in the development of better analgesic agents with fewer side effects (Heinl et al., 2011).

  • Opiate-induced dopamine release is modulated by severity of alcohol dependence: an [(18)F]fallypride positron emission tomography study: This innovative study uses remifentanil to examine how opioid administration affects dopamine release in subjects with varying levels of alcohol dependence. The results are critical for understanding addiction and developing personalized treatment strategies that consider underlying co-dependencies (Spreckelmeyer et al., 2011).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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