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L-048

Supelco

Lidocaine Impurity Mixture solution

20-200 μg/mL in acetonitrile (each analyte), certified reference material, ampule of 1 mL, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C8H11N
Molecular Weight:
121.18
UNSPSC Code:
12352200
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

composition

2,6-Dimethylaniline (Lidocaine RCA), 20 μg/mL
n-(2,6-Dimethylphenyl)chloroacetamide (Lidocaine RCH), 200 μg/mL
Lidocaine, 200 μg/mL

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

20-200 μg/mL in acetonitrile (each analyte)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

multi-component solution

storage temp.

−20°C

General description

Lidocaine is an important antiarrhythmic drug and is used intravenously in the treatment of ventricular arrhythmias. It is also commonly used as a local anesthetic agent due to its ability to block sodium channels in nerves.[1][2][3]

Application

Lidocaine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography method.[4]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Analyte

Description
    Lidocaine, Pharmaceutical Secondary Standard; Certified Reference Material
    Lidocaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
    Lidocaine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material
    Lidocaine Related Compound H, Pharmaceutical Secondary Standard; Certified Reference Material

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

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Certificates of Analysis (COA)

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Lidocaine block of cardiac sodium channels
Bean BP, et al.
The Journal of General Physiology, 81(5), 613-613 (1983)
Pharmacokinetics of lidocaine in man
Boyes RN, et al.
Clinical Pharmacology and Therapeutics, 12(1), 105-116 (1971)
Dexmedetomidine enhances the local anesthetic action of lidocaine via an ?-2A adrenoceptor
Yoshitomi T, et al.
Anesthesia and Analgesia, 107(1), 96-101 (2008)
Lidocaine
USP42-NF37
United States Pharmacopeia/National Formulary, 43(3), 2567-2567 (2013)

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