G-022

Guaifenesin Impurity Mixture solution

0.5-1.0 mg/mL in acetonitrile (each analyte), certified reference material, ampule of 1 mL, Cerilliant^®

• Empirical Formula (Hill Notation): C₇H₈O₂
• Molecular Weight: 124.14
• UNSPSC Code: 12352200
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• composition: Guaiacol, 0.5 mg/mL ; Guaifenesin, 1 mg/mL ; Guaifenesin β-isomer, 0.5 mg/mL
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 0.5-1.0 mg/mL in acetonitrile (each analyte)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): pharmaceutical (small molecule)
• format: multi-component solution
• storage temp.: −20°C

Description

General description

Guaifenesin, a glyceryl ether of guaiacol, is a key constituent in cold and cough formulations. It belongs to the group of expectorant medicines because of its ability to ease the discomfort caused due to cough by causing an increase in the sputum volume and a simultaneous decrease in its viscosity. Its applications include short term relief in the breathing passageway in various conditions such as allergy, cold, and upper respiratory tract infections. It has also been proposed to be effective in the management of pain in various conditions such as prostatitis, seminal vesiculitis, benign prostatic hypertrophy, prostatic abscess, bladder neck hypertrophy, dysmenorrhea, and urinary tract infection.[1][2][3]

Application

Guaifenesin Impurity Mixture solution may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.[4]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Analyte

Guaifenesin, certified reference material, pharmaceutical secondary standard
Guaiacol, Pharmaceutical Secondary Standard; Certified Reference Material
Guaifenesin Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H302 + H312 + H332,H319
• pcodes: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 35.6 °F - closed cup
• flash_point_c: 2.0 °C - closed cup