D-173

Dothiepin HCl (cis/trans) solution

1 mg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₉H₂₁NS · HCl
• CAS Number: 897-15-4
• Molecular Weight: 331.90
• MDL number: MFCD00941484
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1 mg/mL in methanol (as free base)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: S1Cc2c(cccc2)\C(=C\CCN(C)C)\c3c1cccc3.[Cl-].[H+]
• InChI: 1S/C19H21NS.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;
• InChI key: XUPZAARQDNSRJB-CULRIWENSA-N

Description

General description

Dothiepin, also known as Dosulepin and marketed as Prothiaden among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression. Dothiepin also has antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects. Due to its high toxicity and risk of overdose dothiepin is assayed in therapeutic drug monitoring to ensure patients remain within the drug′s therapeutic range. This certified Snap-N-Spike^® solution is suitable for LC-MS/MS applications including therapeutic drug monitoring, clinical toxicology, urine drug testing or forensic analysis.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P280 - P302 + P352 + P312 - P304 + P340 + P311 - P370 + P378 - P403 + P235
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup