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C-035

Supelco

(±)-Cotinine-d3 solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

(+/-)-Cotinine-d3 solution

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About This Item

Empirical Formula (Hill Notation):
C10H9D3N2O
CAS Number:
110952-70-0
Molecular Weight:
179.23
EC Number:
200-659-6
MDL number:
MFCD00083283
UNSPSC Code:
41116107
PubChem Substance ID:
329774776
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

InChI

1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/i1D3

InChI key

UIKROCXWUNQSPJ-FIBGUPNXSA-N

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General description

Cotinine is an alkaloid found in tobacco as well as a major urinary metabolite of nicotine. This stable-labeled internal standard is suitable for quantitation of cotinine levels in urine, blood, and saliva for GC/MS or LC-MS/MS applications in nicotine testing or clinical and diagnostic testing of nicotine biomarkers.

Application


  • (±)-Cotinine-d₃ solution in nicotine metabolism research: This stable isotope-labeled compound is utilized in the HPLC-MS analysis of nicotine and cotinine across various biological matrices, highlighting its critical role in advancing our understanding of nicotine metabolism and exposure in biomedical studies (Jin et al., 2022).

  • Biomarker analysis in passive smoking: Cotinine-d₃ serves as an internal standard in the precise quantification of urinary cotinine, aiding in the assessment of second-hand smoke exposure, particularly in pediatric health studies (Wang et al., 2014).

  • Enhanced analytical techniques for smoking cessation: Employed in a sophisticated UPLC-MS/MS setup, cotinine-d₃ is crucial for quantifying smoking-related biomarkers in clinical trials aimed at evaluating smoking cessation interventions, ensuring accurate and sensitive biomarker tracking (Dobrinas et al., 2011).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

51.8 °F - closed cup

flash_point_c

11.0 °C - closed cup

Certificates of Analysis (COA)

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