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Acetylsalicylic Anhydride (Aspirin Impurity F) solution

100 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C18H14O7
CAS Number:
1466-82-6
Molecular Weight:
342.30
MDL number:
MFCD00013236
UNSPSC Code:
12352200
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

InChI

1S/C18H14O7/c1-11(19)23-15-9-5-3-7-13(15)17(21)25-18(22)14-8-4-6-10-16(14)24-12(2)20/h3-10H,1-2H3

InChI key

OAWXYINGQXLWOE-UHFFFAOYSA-N

General description

Acetylsalicylic Anhydride (ASN) is considered to be an immunogenic impurity of aspirin and the allergic reactions to the drug are attributed to the presence of this impurity.[1]

Application

Acetylsalicylic Anhydride (ASN) may be used as a pharmaceutical reference standard for the determination of trace amounts of analyte in aspirin samples and aspirin formulations by chromatography techniques.[1][2][3]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

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Isolation of salicylsalicylic acid, acetylsalicylsalicylic acid, and acetylsalicylic anhydride from aspirin tablets by extraction and high-pressure liquid chromatography
Reepmeyer JC and Kirchhoefer RD
Journal of Pharmaceutical Sciences, 68(9), 1167-1169 (1979)
Quantitative determination by high-performance liquid chromatography of acetylsalicylic acid and related substances in tablets
Verstraeten A, et al.
Journal of Chromatography A, 388(9), 201-216 (1987)
Application of gas-liquid chromatography and high-performance liquid chromatography to the analysis of trace amounts of salicylic acid, acetylsalicylic anhydride and acetylsalicylsalicylic acid in aspirin samples and aspirin formulations
Ali Syed Laik
Journal of Chromatography A, 126, 651-663 (1976)

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