A-150

Aprobarbital solution

1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₀H₁₄N₂O₃
• CAS Number: 77-02-1
• Molecular Weight: 210.23
• MDL number: MFCD00057559
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• SMILES string: O=C1C(C(C)C)(CC=C)C(NC(N1)=O)=O
• InChI: 1S/C10H14N2O3/c1-4-5-10(6(2)3)7(13)11-9(15)12-8(10)14/h4,6H,1,5H2,2-3H3,(H2,11,12,13,14,15)
• InChI key: UORJNBVJVRLXMQ-UHFFFAOYSA-N

Description

General description

Aprobarbital, also known as aprobarbitone, is sold as Oramon, Somnifaine and Allonal. Aprobarbital has sedative, hypnotic and anticonvulsant properties and was primarily used for the treatment of insomnia. This Snap-N-Spike Reference Solution is applicable for use in applications including clinical toxicology, medication monitoring, urine drug testing, and forensic analysis by LC-MS/MS or GC/MS.

Application

• Rapid quantification of phenobarbital and barbital in human whole blood by liquid-liquid extraction combined with DART-orbitrap-HRMS: This method showcases the use of Aprobarbital-related compounds for forensic toxicology, highlighting its potential in precise legal and clinical diagnostics (Ke et al., 2023).


• Quantitative Determination of Methohexital in Human Whole Blood by Liquid Chromatography Tandem Mass Spectrometry: The study emphasizes the critical role of barbiturates like Aprobarbital in therapeutic monitoring, contributing to safer and more effective drug administration protocols (Zhang et al., 2021).


• Occurrence and fate of barbiturates in the aquatic environment: Research into environmental toxicology of compounds including Aprobarbital, providing insights into pollution control and drug lifecycle analysis (Peschka et al., 2006).


• Determinations of zidovudine/didanosine/nevirapine and zidovudine/didanosine/ritonavir in human serum by micellar electrokinetic chromatography: This analytical technique underlines the broader utility of methodologies applicable to barbiturate analysis like Aprobarbital in complex biological matrices (Fan and Stewart, 2002).


• Determination of lamivudine/stavudine/efavirenz in human serum using liquid chromatography/electrospray tandem mass spectrometry with ionization polarity switch: Demonstrates advanced analytical capabilities potentially extendable to Aprobarbital, enhancing drug monitoring and pharmacokinetic studies (Fan et al., 2002).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes,Central nervous system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup