Skip to Content
MilliporeSigma
All Photos(1)

Documents

900128E

Avanti

15(S)-HETE

Avanti Research™ - A Croda Brand, ethanol solution

Synonym(s):

15S-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C20H32O3
CAS Number:
54845-95-3
Molecular Weight:
320.47
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

ethanol solution

packaging

pkg of 1 × 1 mL (900128E-100UG)
pkg of 1 × 1 mL (900128E-500UG)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

100 μg/mL in ethanol (900128E-100UG)
500 μg/mL in ethanol (900128E-500UG)

shipped in

dry ice

storage temp.

−70°C

InChI

1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1

InChI key

JSFATNQSLKRBCI-VAEKSGALSA-N

General description

15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).

Biochem/physiol Actions

15(S)-HETE plays a role in various biological actions. It may play a role in pathogenesis and prevention of airway inflammatory disorders. 15(S)-HETE is involved in inhibiting cell proliferation and induces apoptosis in various human cancers.

Packaging

2 mL Amber Glass Sealed Ampule (900128E-100UG and 900128E-500UG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

hcodes

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

55.4 °F

flash_point_c

13 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

15 (S)-HETE modulates LTB4 production and neutrophil chemotaxis in chronic bronchitis
Profita M, et al.
American Journal of Physiology. Cell Physiology, 279(4), C1249-C1258 (2000)
Huiling Yuan et al.
Thorax, 65(4), 321-326 (2010-04-15)
15-S-Hydroxyeicosatetraenoic acid (15(S)-HETE) and 13-S-hydroxyoctadecadienoic acid (13(S)-HODE), both of which are metabolites of 15-lipoxygenases (15-LOXs), are endogenous ligands for peroxisome proliferator-activated receptor gamma (PPARgamma). The activation of PPARgamma inhibits cell growth and induces apoptosis in some cancers. The role of

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service