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890701C

Avanti

14:0 EPC (Cl Salt)

Avanti Research™ - A Croda Brand 890701C

Synonym(s):

1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

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About This Item

Empirical Formula (Hill Notation):
C38H77NO8PCl
CAS Number:
186492-53-5
Molecular Weight:
742.45
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 1 mL (890701C-10mg)
pkg of 1 × 2.5 mL (890701C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 890701C

concentration

10 mg/mL (890701C-10mg)
10 mg/mL (890701C-25mg)

lipid type

transfection
cationic lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O)OCC.[Cl-]

Application

14:0 EPC (Cl Salt) is suitable:
  • for combining with a co-lipid, in liposome preparation by sonication[1]
  • for the preparation of cationic lipid mixtures to establish its superior transfection activity[2]
  • for the study of dehydration dynamics[3]

Biochem/physiol Actions

14:0 EPC (Cl Salt) is a cationic lipid. It efficiently mediates gene delivery into the cells.[4] 14:0 EPC (Cl Salt) serves as a non-viral delivery vector.[1]

Packaging

5 mL Clear Glass Sealed Ampule (890701C-10mg)
5 mL Clear Glass Sealed Ampule (890701C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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Efficient in vivo delivery of DNA to pulmonary cells using the novel lipid EDMPC
Gorman CM
Gene Therapy, 4(9), 983-983 (1997)
The dehydration dynamics of a model cell membrane induced by cholesterol analogue 6-ketocholestanol investigated using sum frequency generation vibrational spectroscopy
Ma S, et al.
Science China: Chemistry, 58(7), 1176-1186 (2015)
Aspects of nonviral gene therapy: correlation of molecular parameters with lipoplex structure and transfection efficacy in pyridinium-based cationic lipids
Parvizi P, et al.
International Journal of Pharmaceutics, 461(1-2), 145-156 (2014)
Analysis of lipoplex structure and lipid phase changes
Liposomes, 399-423 (2010)
Rumiana Koynova et al.
The journal of physical chemistry. B, 111(27), 7786-7795 (2007-06-19)
Some mixtures of two cationic lipids including phospholipid compounds (O-ethylphosphatidylcholines) as well as common, commercially available cationic lipids, such as dimethylammonium bromides and trimethylammonium propanes, deliver therapeutic DNA considerably more efficiently than do the separate molecules. In an effort to
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