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880410C

Avanti

14:0 PEG350 PE

Avanti Research™ - A Croda Brand 880410C

Synonym(s):

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350] (ammonium salt)

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About This Item

CAS Number:
474922-82-2
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 2.5 mL (880410C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880410C

concentration

10 mg/mL (880410C-25mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O.[NH4+]

General description

14:0 PEG350 PE is a polyethylene glycol (PEG) conjugated phospholipid. PEGylated phospholipids are amphiphilic polymers.[1]
Poly (ethylene glycol)s (PEGs)- phosphatidylethanolamines (PEs) lipids are anionic double tailed lipids. Its structure contains a wedge shaped bulky hydrophilic polar head.[2]

Application

14:0 PEG350 PE is suitable for use in the preparation of floating bilayer lipid membrane to mimic the environment of a biological cell membrane.[3]

Biochem/physiol Actions

Liposome formulation commonly incorporates polyethylene glycol (PEG) conjugated phospholipids,[4] as they efficiently maintain their stereochemistry.[5] They are also used as drug carriers.[6] The formation of mixed micelles is supported by the use of highly concentrated PEG-lipids.[5]
Poly (ethylene glycol)s (PEGs)- phosphatidylethanolamines (PEs) lipids are key constituents of sterically stabilized liposomes, which are used as drug vehicles.[2]

Packaging

5 mL Clear Glass Sealed Ampule (880410C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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Electrochemical and PM-IRRAS studies of floating lipid bilayers assembled at the Au (111) electrode pre-modified with a hydrophilic monolayer
Su Z, et al.
Journal of Electroanalytical Chemistry, 688, 76-85 (2013)
Rosa Bartucci et al.
Chemistry and physics of lipids, 124(2), 111-122 (2003-06-24)
Conventional electron spin resonance (ESR) spectroscopy of different positional isomers of phosphatidylcholine spin labels (n-PCSL; n=5, 7, 10, 12, 14, and 16) has been used to study micellar dispersions made of poly(ethylene glycol)s-phosphatidylethanolamines (PEGs-PEs) polymer-lipids. Such aggregates are currently used
Micro- and Nanoengineering of the Cell Surface (2014)
Sirkku Hanski et al.
Biomacromolecules, 11(12), 3440-3447 (2010-10-27)
We report on highly ordered oblique self-assemblies in ionic complexes of PEGylated triple-tail lipids and cationic polypeptides, as directed by side-chain crystallization, demonstrating also reversible oblique-to-hexagonal order-order transitions upon melting of the side chains. This is achieved in bulk by
G F Peacock et al.
Drug delivery, 10(1), 29-34 (2003-01-30)
A new cholesterol-carborane conjugate (BCH) has been synthesized as a potential targeting agent for boron neutron capture therapy (BNCT) of cancers. The compound is extremely water insoluble and was formulated in two liposomal formulations to determine if the compound could
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