878118P
Avanti
C16-02:0 DG
Avanti Research™ - A Croda Brand 878118P, powder
Synonym(s):
1-O-hexadecyl-2-acetyl-sn-glycerol (HAG)
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About This Item
Empirical Formula (Hill Notation):
C21H42O4
CAS Number:
Molecular Weight:
358.56
UNSPSC Code:
12352211
NACRES:
NA.25
form
powder
packaging
pkg of 1 × 5 mg (with screw cap (878118P-5mg))
manufacturer/tradename
Avanti Research™ - A Croda Brand 878118P
shipped in
dry ice
Storage temp.
−20°C
SMILES string
OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC
General description
C16-02:0 DG, also called as 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG), is an alkylacylglycerol and a bioactive lipid. Structurally, HAG contains primary alcohol group at the C3 position.[1]
Application
C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG) may be used to prevent 1-O-acyl-NAS formation.[1]
Biochem/physiol Actions
C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG) is a diacylglycerol (DAG) antagonist with a potential to inhibit protein kinase C (PKC) activity.[2] It also has an ability to inhibit growth of human promyelocytic leukemia cell line HL-60.[3] HAG serves as a precursor in the biosynthesis of platelet-activating factor.[1]
Packaging
5 mL PTFE Vial with Screw Cap (878118P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
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M J McNamara et al.
Biochemical and biophysical research communications, 122(2), 824-830 (1984-07-31)
The human promyelocytic leukemia cell line HL-60 can be differentiated to cells resembling either neutrophils or mononuclear phagocytes by a diverse group of stimuli. However, the underlying mechanisms remain unknown. We report that 1-0-hexadecyl-2-acetyl-sn-glycerol inhibits the growth of HL-60 cells
Jin Tao et al.
Cellular signalling, 21(9), 1436-1443 (2009-05-15)
Corticotropin-releasing factor (CRF) receptors have been demonstrated to be widely expressed in the central nervous system and in many peripheral tissues of mammalians. However, it is still unknown whether CRF receptors will function in cerebellar Purkinje neurons. In the present
Akira Abe et al.
Journal of lipid research, 48(10), 2255-2263 (2007-07-14)
A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned. LPLA2 transfers sn-1 or sn-2 acyl groups of phospholipids to the C1 hydroxyl of the short-chain ceramide N-acetylsphingosine (NAS) under acidic conditions. The
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