878115P
Avanti
C16-04:0 PC
Avanti Research™ - A Croda Brand 878115P, powder
Synonym(s):
1-O-hexadecyl-2-butyryl-sn-glycero-3-phosphocholine
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About This Item
Empirical Formula (Hill Notation):
C28H58NO7P
CAS Number:
Molecular Weight:
551.74
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 5 mg (878115P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 878115P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCC)=O)COCCCCCCCCCCCCCCCC)=O
General description
C16-04:0 PC, also known as 1-O-hexadecyl-2-butyryl-sn-glycero-3-phosphocholine (butanoyl-PAF), is a platelet-activating factor (PAF) analog belonging to the class of bioactive lipids. It is produced non-enzymatically in the oxidized-low density lipoprotein (Ox-LDL) particle. [1] Butanoyl-PAF contains ether-linked hexadecyl chain at the sn-1 position and a butyryl group at the sn-2 position. It is mostly produced in body during high oxidative stress. This lipid mediator acts as a pro-inflammatory agent.[1]
Application
C16-04:0 PC or 1-O-hexadecyl-2-butyryl-sn-glycero-3-phosphocholine is suitable to study its physicochemical properties and its association with peptides derived from the C-terminal domains of human apolipoprotein E.[1]
Packaging
5 mL Clear Glass Sealed Ampule (878115P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
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Sunil A Nankar et al.
Biochimie, 95(6), 1196-1207 (2013-02-05)
Apolipoprotein-derived peptides are promising candidates for the treatment of various inflammatory conditions and the main mechanism proposed for the protective action of these peptides includes binding to pro-inflammatory lipid mediators with high affinity and facilitating their sequestration/metabolism/clearance in the body.
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