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870625P

Avanti

Trans-AzCA4

Avanti Research™ - A Croda Brand (870625P), powder

Synonym(s):

(E)-4-(4-[(4-butylphenyl)diazenyl]phenyl)-N-(3-hydroxy-4-methoxybenzyl)butanamide

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About This Item

Empirical Formula (Hill Notation):
C28H33N3O3
CAS Number:
2260670-59-3
Molecular Weight:
459.58
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (870625P-25MG)
pkg of 1 × 5 mg (870625P-5MG)

manufacturer/tradename

Avanti Research™ - A Croda Brand (870625P)

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(CCCC1=CC=C(/N=N/C2=CC=C(CCCC)C=C2)C=C1)NCC3=CC(O)=C(OC)C=C3

InChI

1S/C28H33N3O3/c1-3-4-6-21-9-14-24(15-10-21)30-31-25-16-11-22(12-17-25)7-5-8-28(33)29-20-23-13-18-27(34-2)26(32)19-23/h9-19,32H,3-8,20H2,1-2H3,(H,29,33)/b31-30+

InChI key

OHCVQWRUXLESDK-NVQSTNCTSA-N

General description

Azo-capsaicin (AzCAs) is a photo-switchable agonist of vanilloid receptor 1 (TRPV1). Azo-capsaicin 4 (AzCA4) is the most effective agonist for TRPV1. It is composed of a capsaicin head and an azobenzene ring having photoswitchable fatty acid tail.[1] AzCA4 exists as two isomers, which are cis- and trans- AzCA4.[2]

Packaging

5 mL Amber Glass Screw Cap Vial (870625P-5MG and 870625P-25MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions
Curcic S, et al.
Pharmacology & Therapeutics, 200, 13-26 (2019)
James Allen Frank et al.
Nature communications, 6, 7118-7118 (2015-05-23)
Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA analogues (FAAzos) that incorporate an azobenzene photoswitch along the FA chain. By

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