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860647P

Avanti

C18:1 Ceramide (d17:1/18:1(9Z))

Avanti Research™ - A Croda Brand 860647P, powder

Synonym(s):

N-oleoyl-D-erythro-sphingosine (C17 base)

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About This Item

Empirical Formula (Hill Notation):
C35H67NO3
CAS Number:
352518-73-1
Molecular Weight:
549.91
UNSPSC Code:
12352100
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 10 mg (860647P-10mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860647P

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCC/C=C\CCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCC

General description

C18:1 Ceramide (d17:1/18:1(9Z)) is a synthetic ceramide containing C17 analog of sphingosine with oleic acid.[1] It is the key component of cell membranes.[2]

Application

C18:1 Ceramide (d17:1/18:1(9Z)) has been used as an internal standard to quantify ceramides in muscles by Agilent 6460 triple quadrupole mass spectrometry.[3]

Biochem/physiol Actions

Ceramides acts as a precursor for various sphingolipids. Ceramides play an important role in cell differentiation, proliferation, and apoptosis. In addition, it also acts as a secondary transmitter in cell signaling.[2] C18 species of ceramide is particularly involved in cell growth inhibition.[4]

Packaging

5 mL Amber Glass Screw Cap Vial (860647P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

No data available

flash_point_c

No data available

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Yang Wang et al.
The Journal of nutritional biochemistry, 64, 182-197 (2018-12-12)
Metabolic syndrome components, including obesity, dyslipidemia and impaired glucose homeostasis, become a major public health issue. Muscles play a predominant role in insulin-mediated glucose uptake, and high fat diets may negatively affect muscle function and homeostasis. This work aimed to
Takhar Kasumov et al.
Analytical biochemistry, 401(1), 154-161 (2010-02-25)
We present an optimized and validated liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method for the simultaneous measurement of concentrations of different ceramide species in biological samples. The method of analysis of tissue samples is based on Bligh and
Anna Zalewska et al.
Biomolecules, 9(12) (2019-12-19)
This is the first study to investigate the relationship between ceramides, the mitochondrial respiratory system, oxidative stress, inflammation, and apoptosis in the submandibular gland mitochondria of mice with insulin resistance (IR). The experiment was conducted on 20 male C57BL/6 mice
Luisa Coderch et al.
American journal of clinical dermatology, 4(2), 107-129 (2003-01-30)
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular spaces of the stratum corneum. These lamellar sheets are thought to provide the barrier property of the epidermis. It is generally accepted that the intercellular lipid domain
Hady Razak Hady et al.
Journal of clinical medicine, 8(12) (2019-12-18)
The liver plays a central role in the glucose and lipid metabolism. Studies performed on animal models have shown an important role of lipid accumulation in the induction of insulin resistance. We sought to explain whether in obese humans, the

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