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860603P

Avanti

Phytosphingosine Phosphocholine

Avanti Research™ - A Croda Brand, powder

Synonym(s):

4-hydroxysphinganine-1-phosphocholine (Saccharomyces Cerevisiae)

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About This Item

Empirical Formula (Hill Notation):
C23H51N2O6P
Molecular Weight:
482.63
UNSPSC Code:
12352211
NACRES:
NA.25

assay

99% (TLC)

form

powder

packaging

1 ea of 5 mg (860603P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@]([H])(CCCCCCCCCCCCCC)[C@](O)([H])[C@](N)([H])COP([O-])(OCC[N+](C)(C)C)=O

General description

Phytosphingosine phosphocholine is a sphingolipid containing phytosphingosine conjugated with phosphocholine. Phytosphingosine is a sphingoid and it is majorly found in plants, fungi and epidermis of mammals.[1][2] Phytosphingosine contains an additional hydroxyl group at C-4, which is localized to the small intestine and and skin.[3] It is an important long chain base (LCB) in yeast.[3] Phosphatidylcholine (PC) is a glycerophospholipid, that constitutes 40-50% of the total phospholipid content in the cell membrane.[4][5] It is an abundant phospholipid in all mammalian cells and cellular organelles.[4]

Packaging

5 mL Amber Glass Screw Cap Vial

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Phytosphingosine enhances moisture level in human skin barrier through stimulation of the filaggrin biosynthesis and degradation leading to NMF formation
Choi H K, et al.
Archives of Dermatological Research, 309(10), 795-803 (2017)
The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease.
van der Veen J N, et al.
Biochimica et Biophysica Acta - Biomembranes, 1859(9 Pt B), 1558-1558 (2017)
Phosphatidylethanolamine and phosphatidylcholine biosynthesis by the Kennedy pathway occurs at different sites in Trypanosoma brucei
Farine L, et al.
Scientific Reports, 5(9 Pt B), 16787-16787 (2015)
Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids
Kondo N, et al.
Nature Communications, 5(1), 1-13 (2014)
Byung-Hak Kim et al.
The Journal of investigative dermatology, 134(4), 1023-1032 (2013-11-02)
Phytosphingosine is abundant in plants and fungi and is found in mammalian epidermis, including the stratum corneum. Phytosphingosine and its derivatives N-acetyl phytosphingosine and tetraacetyl phytosphingosine are part of the natural defense system of the body. However, these molecules exhibit

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