860460P
Avanti
N-C12-deoxysphinganine
N-lauroyl-1-deoxysphinganine (m18:0/12:0), powder
Synonym(s):
N-dodecanoyl-1-deoxysphinganine (m18:0/12:0); N-C12-1-deoxyDHCer; 110958
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About This Item
Empirical Formula (Hill Notation):
C30H61NO2
CAS Number:
Molecular Weight:
467.81
UNSPSC Code:
12352211
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860460P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860460P
shipped in
dry ice
storage temp.
−20°C
General description
Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), this product is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The biological activity of 1-deoxyDHCer is not clearly understood at this time.
N-C12-deoxysphinganine is found in mammalian cells. It may be associated with neuronal toxicity.
Packaging
5 mL Amber Glass Screw Cap Vial (860460P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
Certificates of Analysis (COA)
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Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue
Schwartz NU, et al.
Prostaglandins & other lipid mediators (2019)
Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals
Zitomer NC, et al.
The Journal of Biological Chemistry, 284(8), 4786-4795 (2009)
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