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860020P

Avanti

Egg Sphingosine

D-erythro-Sphingosine (Egg, Chicken), powder

Synonym(s):

Sphingosine 2S, 3R; D-erythro-sphingosine; (2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol; (2S,3R,4E)-2-amino-1,3-octadec-4-enediol

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About This Item

CAS Number:
475662-41-0
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (860020P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860020P

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1

InChI key

WWUZIQQURGPMPG-KRWOKUGFSA-N

General description

Egg sphingosine is a central metabolite, which arises from the de novo synthesis of cellular sphingolipids. It modulates growth, differentiation, survival and cell death. Egg sphingosine functions as a pharmacological inhibitor of protein kinase C in human platelets. It is also implicated in inhibiting platelet aggregation in cells.

Application

Egg sphingosine has been used to study protein-lipid interaction.

Packaging

5 mL Amber Glass Screw Cap Vial (860020P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets
Khan WA, et al.
The Biochemical Journal, 278(2), 387-392 (1991)
Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine
Grimm C, et al.
Molecular Pharmacology, 67(3), 798-805 (2005)
Mathias J Gerl et al.
PloS one, 11(4), e0153009-e0153009 (2016-04-23)
Cell membranes contain hundreds to thousands of individual lipid species that are of structural importance but also specifically interact with proteins. Due to their highly controlled synthesis and role in signaling events sphingolipids are an intensely studied class of lipids.

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