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857382P

Avanti

SLC5111312

Avanti Research™ - A Croda Brand, powder

Synonym(s):

(2R,3S)-3-hydroxy-2-(3-(6-(pentyloxy)naphthalen-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide

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About This Item

Empirical Formula (Hill Notation):
C22H27N5O3
CAS Number:
1449768-48-2
Molecular Weight:
409.48
UNSPSC Code:
12352211
NACRES:
NA.25

assay

99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (857382P-1MG)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

Storage temp.

−20°C

SMILES string

N=C(N)N1CC[C@H](O)[C@@H]1C2=NC(C3=CC4=CC=C(OCCCCC)C=C4C=C3)=NO2

General description

SLC5111312 is a selective inhibitor of mouse sphingosine kinase 2 (SphK2). It also inhibits rat and human sphingosine kinase type 1 and type 2 (SphK1/2).[1][2] It is made up of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group.[2]

Biochem/physiol Actions

SLC5111312 increases the blood sphingosine 1-phosphate (S1P) levels in mice due to the inhibition of sphingosine kinase type 2 (SphK2).[1][2]

Packaging

5ML Amber Glass Screw Cap Vial (857382P-1MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors
Kharel Y, et al.
PLoS ONE, 13(4), 23-31 (2018)
Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels
Kharel Y, et al.
Journal of Pharmacology and Experimental Therapeutics, 355(1), 23-31 (2015)

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