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857367P

Avanti

VPC 23153

Avanti Research™ - A Croda Brand 857367P, powder

Synonym(s):

(R)-phosphoric acid mono-[2-amino-2-(6-octyl-1H-benzoimiazol-2-yl)-ethyl] ester

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About This Item

Empirical Formula (Hill Notation):
C17H28N3O4P
CAS Number:
787582-98-3
Molecular Weight:
369.40
UNSPSC Code:
12352211

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (857367P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 857367P

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCC1=CC=C2C(N=C([C@H](COP(O)([O-])=O)[NH3+])N2)=C1

Application

VPC 23153 has been used to study its effects in isolated pulmonary, renal and mesenteric arteries.[1] It has also been used to study its pharmacological properties at the human sphingosine 1-phosphate 3 (S1P3)receptor expressed in Chinese hamster ovary (CHO) FlpIn cells.[2]

Biochem/physiol Actions

VPC 23153 is a sphingosine 1-phosphate 4 (S1P4) receptor agonist. It is associated with the contraction of pulmonary arteries in rats.[1]

Packaging

5 mL Amber Glass Screw Cap Vial (857367P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Hiroki Ota et al.
Pulmonary circulation, 1(3), 399-404 (2011-12-06)
This study aimed to identify receptors mediating sphingosine-1-phosphate (S1P)-induced vasoconstriction in the normotensive and chronic hypoxia-induced hypertensive rat pulmonary circulation. In isolated perfused lungs from normoxic rats, infusion of S1P caused a sustained vasoconstriction, which was not reduced by combinational
M Jongsma et al.
British journal of pharmacology, 156(8), 1305-1311 (2009-03-25)
Recently, some ligands targeting the sphingosine-1-phosphate receptor subtype 3 (S1P(3)) have become available. The characterization of these compounds was mainly based on one functional read-out system, although S1P(3) receptors are known to activate different signal transduction pathways. Therefore, this study

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