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857365P

Avanti

VPC 24191

Avanti Research™ - A Croda Brand 857365P, powder

Synonym(s):

(S)-phosphoric acid mono-[2-amino-3-(4-octyl-phenylamino)-propyl] ester

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About This Item

Empirical Formula (Hill Notation):
C17H31N2O4P
CAS Number:
799268-83-0
Molecular Weight:
358.41
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (857365P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 857365P

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCC1=CC=C(NC[C@@H](COP(O)([O-])=O)[NH3+])C=C1

InChI

1S/C17H31N2O4P/c1-2-3-4-5-6-7-8-15-9-11-17(12-10-15)19-13-16(18)14-23-24(20,21)22/h9-12,16,19H,2-8,13-14,18H2,1H3,(H2,20,21,22)/t16-/m0/s1

InChI key

VRQMZRZONPRMOX-INIZCTEOSA-N

Application

VPC 24191 has been used as a sphingosine 1-phosphate (S1P) receptor agonist for various experiments in human bone marrow-derived mesenchymal stem cells overexpressing human telomerase reverse transcriptase (hMSC-TERT) cell treatments and bovine adrenal glomerulosa cells.[1][2] It has also been used to study its pharmacological properties at the human S1P3 receptor expressed in CHO FlpIn cells.[3]

Biochem/physiol Actions

VPC 24191 acts as a sphingosine 1-phosphate (S1P1/3) receptor agonist.[2]

Packaging

5 mL Amber Glass Screw Cap Vial (857365P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Leyre Brizuela et al.
Journal of lipid research, 48(10), 2264-2274 (2007-07-05)
We reported recently that sphingosine-1-phosphate (S1P) is a novel regulator of aldosterone secretion in zona glomerulosa cells of adrenal glands and that phospholipase D (PLD) is implicated in this process. We now show that S1P causes the phosphorylation of protein
Patrick Quint et al.
The Journal of biological chemistry, 288(8), 5398-5406 (2013-01-10)
Normal bone turnover requires tight coupling of bone resorption and bone formation to preserve bone quantity and structure. With aging and during several pathological conditions, this coupling breaks down, leading to either net bone loss or excess bone formation. To
M Jongsma et al.
British journal of pharmacology, 156(8), 1305-1311 (2009-03-25)
Recently, some ligands targeting the sphingosine-1-phosphate receptor subtype 3 (S1P(3)) have become available. The characterization of these compounds was mainly based on one functional read-out system, although S1P(3) receptors are known to activate different signal transduction pathways. Therefore, this study

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