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855777C

Avanti

20:0 Lyso PC

Avanti Research™ - A Croda Brand

Synonym(s):

1-eicosanoyl-sn-glycero-3-phosphocholine; PC(20:0/0:0)

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About This Item

Empirical Formula (Hill Notation):
C28H58NO7P
CAS Number:
108341-80-6
Molecular Weight:
551.74
UNSPSC Code:
51191904
NACRES:
NA.25

description

1-arachidoyl-2-hydroxy-sn-glycero-3-phosphocholine, chloroform

assay

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (855777C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (855777C-25mg)

shipped in

dry ice

storage temp.

−20°C

General description

Lysophosphatidylcholine (Lyso-PC) is a component of blood plasma, vascular tissue and lipoproteins.[1]

Application

20:0 Lyso PC has been used as an internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) to quantify very long chain fatty acids (VLCFA) levels in peroxisome biogenesis disorders (PBD) cell lines.[2]

Biochem/physiol Actions

Lysophosphatidylcholine (Lyso-PC) is associated with inflammatory diseases and atherosclerosis.[3] It stimulates the expression of genes for growth factors and cellular adhesion molecules.[1]

Packaging

5 mL Clear Glass Sealed Ampule (855777C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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Development and validation of a UHPLC-ESI-MS/MS method for the simultaneous quantification of mammal lysophosphatidylcholines and lysophosphatidylethanolamines in serum
Suarez-Garcia S, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1055, 86-97 (2017)
The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders
Law KB, et al.
Autophagy, 13(5), 868-884 (2017)
Lysophosphatidylcholine stimulates the release of arachidonic acid in human endothelial cells
Wong JT, et al.
Test, 273(12), 6830-6836 (1998)
Kelsey B Law et al.
Autophagy, 13(5), 868-884 (2017-05-20)
Peroxisome biogenesis disorders (PBDs) are metabolic disorders caused by the loss of peroxisomes. The majority of PBDs result from mutation in one of 3 genes that encode for the peroxisomal AAA ATPase complex (AAA-complex) required for cycling PEX5 for peroxisomal

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