855774C

2-18:0 Lyso PC

Avanti Research^™ - A Croda Brand 855774C

• Synonym(s): 2-stearoyl-sn-glycero-3-phosphocholine
• Empirical Formula (Hill Notation): C₂₆H₅₄ NO₇P
• CAS Number: 4421-58-3
• Molecular Weight: 523.68
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• assay: >99% (TLC)
• form: liquid
• packaging: pkg of 1 × 1 mL (855774C-1mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 855774C
• concentration: 1 mg/mL (855774C-1mg)
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)CO)=O

Description

General description

2-18:0 Lyso PC is one of the degradation products of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC).[1]

2-18:0 Lyso PC or lyso-phosphatidylcholine (LPC) is a bioactive proinflammatory lipid produced on pathological response.[2] It contains choline group at its polar head.[3]

Application

2-18:0 Lyso PC may be used to study the influence of cholesterol and β-sitosterol on the structure of phosphatidylcholine bilayers.[4] It may also be used as a reference standard for its determination in 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) formulations by a reverse-phase liquid chromatography charged aerosol detection (RPLC-CAD) technique.[1]

Biochem/physiol Actions

Lysophosphatidylcholine (LPC) alters several biological activities in various cell-types, including endothelial cells, smooth muscle cells, monocytes, macrophages and T-cells and leads to the development of atherosclerosis and inflammatory diseases. In addition, it also facilitates the activation of many second messengers such as, protein kinase C, extracellular-signal-regulated kinases and protein tyrosine kinases.[2]

Packaging

5 mL Clear Glass Sealed Ampule (855774C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• pcodes: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• target_organs: Central nervous system, Liver,Kidney
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: does not flash
• flash_point_c: does not flash